Dr. Guilherme Silva

Guilherme Silva, MD, earned his medical degree from the Federal University of Rio de Janeiro in Brazil. Upon completing his medical degree, he did 3 years of Cardiology training in Brazil. After coming to the United States, he completed 3 years of postgraduate training in Internal Medicine at The University of Texas-Houston. At the Texas Heart Institute in Houston, he completed a 3-year general Cardiology fellowship and 1 year of Interventional Cardiology training.

 

During his training at the Texas Heart Institute, Dr. Silva held the position of Chief Cardiology Fellow and Chief Interventional Cardiology Fellow and was chosen as the outstanding cardiology fellow of the 2007 graduating class. Dr Silva has been heavily involved in cardiovascular disease research and is one of the pioneers in the utilization of stem cells for treating heart attacks and heart failure. Currently, Dr. Silva holds the position of Assistant Medical Director of the Stem Cell Center at the Texas Heart Institute.

 

Dr. Silva has received training in general cardiology, nuclear cardiology, echocardiography, and interventional cardiology techniques, including cardiac catheterization, percutaneous transluminal coronary angioplasty (PTCA), coronary stenting, peripheral vascular angioplasty and stenting, and rotational atherectomy.

 

He is board certified in Internal Medicine, Cardiovascular Disease, Nuclear Cardiology, and Echocardiography.


Education, Publications and Presentations

 

Professional Appointments

Cardiologist and Interventional Cardiologist
Southwest Cardiovascular Consultants, Inc.
Houston, Texas
 
Assistant Medical Director
Stem Cell Research Center
Texas Heart Institute
Houston, Texas
 
Clinical Assistant Professor
Baylor College of Medicine
Houston, Texas

Awards and Honors

Chief Cardiology Fellow
Texas Heart Institute/Baylor College of Medicine
Houston, Texas
 
Chief Interventional Cardiology Fellow
Texas Heart Institute/Baylor College of Medicine
Houston, Texas
 
The Tauber Award for the Texas Heart Institute
Outstanding Cardiology Fellow
Academic Year 2006-2007

 


  • Education
  • Articles
  • Book Chapters
  • Abstracts
  1. Adult Cardiology and Adult Interventional Cardiology Fellowship, Texas Heart Institute at St. Luke’s Episcopal Hospital, Houston, Texas

  2. Adult Cardiology and Adult Interventional Cardiology Fellowship, Texas Heart Institute at St. Luke’s Episcopal Hospital and Baylor College of Medicine, Houston, Texas

  3. Adult Cardiology Research Fellowship, Texas Heart Institute and Baylor College of Medicine, Houston, Texas

  4. Residency, Internal Medicine, Memorial Hermann Hospital, Lyndon B. Johnson General Hospital, The University of Texas M. D. Anderson Cancer Center, St. Luke’s Episcopal Hospital, The University of Texas-Houston

  5. Residency, Cardiology Pedro Ernesto Hospital, State University of Rio de Janeiro, Rio de Janeiro, Brazil

  6. MD, School of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil

  1. Leite RS, Silva GV, Goulart LC, Gottschall CA, Perin EC. A sewing needle in the right ventricle. Tex Heart Inst J 2000;27(3):314-315.

  2. Perin EC, Silva GV, Leite RS. Left ventricular electromechanical mapping: A case study of functional assessment in coronary intervention. Tex Heart Inst J 2000;27(3);253-256.

  3. Perin EC, Leite RS, Silva GV, Rogers MD, Topaz O. “Wireless” laser recanalization of chronic total occlusions. J Invasive Cardiol 2001;13(5):401-405.

  4. Perin EC, Silva GV, Sarmento-Leite R, Vaughn WK, Fish RD, Ferguson JJ. Left ventricular electromechanical mapping: preliminary evidence of electromechanical changes after successful coronary intervention. Am Heart J 2002;144(4):693-701.

  5. Perin EC, Silva GV, Sarmento-Leite R, Sousa AL, Howell M, Muthupillai R, Lambert B, Vaughn WK, Flamm SD. Assessing myocardial viability and infarct transmurality with left ventricular electromechanical mapping in patients with stable coronary artery disease: validation by delayed-enhancement magnetic resonance imaging. Circulation 2002;106(8);957-961.

  6. Leite RS, Silva GV, Dohmann HFR, Rocha RM, Dohmann HF, Mattos NDSG, Carvalho LA, Perin EC. Comparison of left ventricular electromechanical mapping and left ventricular angiography: defining practical standards for the analysis of NOGA maps. Tex Heart Inst J 2003;30(1):19-26.

  7. Perin EC, Dohmann HF, Borojevic R, Silva SA, Sousa AL, Mesquita CT, Rossi, MI, Carvalho AC, Dutra HS, Dohmann HJ, Silva GV, Belém L, Vivacqua R, Rangel FO, Esporcatte R, Geng YJ, Vaughn WJ, Assad JA, Mesquita ET, Willerson JT.  Transendocardial, autologous bone-marrow cell transplant for severe, chronic ischemic heart failure. Circulation 2003;107:2294-2302.

  8. Rocha RM, Silva GV, Perin EC, Gerk AR, Gouveau EP, Santos VMS, Filho FMA, Albuquerque DC. Effects of carvedilol therapy on QT-interval dispersion in congestive heart failure. Tex Heart Inst J 2003;30(3)176-179.

  9. Silva GV, Litovsky S, Assad JAR, Sousa ALS, Martin BJ, Vela D, Coulter SC, Lin J, Ober J, Vaughn WK, Branco RVC, Oliveira EM, He R, Geng Y, Willerson JT, Perin EC. Mesenchymal stem cells differentiate into an endothelial phenotype, enhance vascular density, and improve heart function in a canine chronic ischemia model. Circulation 2005;111:150-156.

  10. Perin EC, Silva GV. Stem cell therapy for cardiac diseases. Curr Opin Hematol 2004;11(6); 399-403.

  11. Silva GV, Perin EC, Dohmann HF, Borojevic R, Silva SA, Sousa AL, Assad JA, Vaughn WK, Mesquita CT, Belem L, Carvalho AC, Dohmann HJ, Barroso do Amaral E, Coutinho J, Branco R, Oliveira E, Willerson JT.Catheter-based transendocardial delivery of autologous bone-marrow-derived mononuclear cells in patients listed for heart transplantation. Tex Heart Inst J 2004;31(3):214-219.

  12. Dohmann HF, Perin EC, Borojevic R, Silva SA, Souza AL, Silva GV, Assad JA, Rossi MI, Mesquita CT, Dohmann HJ. Sustained improvement in symptoms and exercise capacity up to six months after autologous transendocardial transplantation of bone marrow mononuclear cells in patients with severe ischemic heart disease. Arq Bras Cardiol 2005;84(5):360-366.

  13. Dohmann HF, Perin EC, Takiya CM, Silva GV, Silva SA, Sousa AL, Mesquita CT, Rossi MI, Pascarelli BM, Assis IM, Dutra HS, Assad JA, Castello-Branco RV, Drummond C, Dohmann HJ, Willerson JT, Borojevic R. Transendocardial autologous bone marrow mononuclear cell injection in ischemic heart failure: postmortem anatomicopathologic and immunohistochemical findings. Circulation 2005;112(4):521-526.

  14. Perin EC, Dohmann HF, Borojevic R, Silva SA, Sousa AL, Silva GV, Mesquita CT, Belem L, Vaughn WK, Rangel FO, Assad JA, Carvalho AC, Branco RV, Rossi MI, Dohmann HJ, Willerson JT. Improved exercise capacity and ischemia 6 and 12 months after transendocardial injection of autologus bone marrow mononuclear cells for ischemic cardiomyopathy. Circulation 2004;110(11 Suppl1):II213-8.

  15. Silva GV, Souosa AL, Asad JA, Olivera E, Angeli F, Lopez J, Jimenez-Quevedo P, Willerson JT, Perin EC. Intracoronary infusion of mesenchymal stem cells is associated with decreased coronary flow and myocardial injury in dogs with normal coronaries. Circulation 2005;112(17):II-120.

  16. Silva GV, Litovsky S, Assad JAR, Sousa ALS, Martin BJ, Vela D, Coulter SC, Lin J, Ober J, Vaughn WK, Branco RVC, Oliveira EM, He R, Geng Y, Willerson JT, Perin EC. Mesenchymal stem cells differentiate into an endothelial phenotype, enhance vascular density, and improve heart function in a canine chronic ischemia model. Circulation 2005;111:150-156.

  17. Shaan de Quandros A, Sarmento-Leite R, Gottschall CAM, Silva GV, Perin EC. Hyperexpansion of coronary stents and clinical outcomes. Tex Heart Inst J 2006;33:437-444.

  18. Fernandes MR, Silva GV, Caixeta A, Rati M, de Sousa e Silva NA, Perin EC. Assessing intermediate coronary lesions: angiographic prediction of lesion severity on intravascular ultrasound. J Invasive Cardiol 2007;19(10):412-416.

  19. Perin EC, Silva GV, Assad JA, Vela D, Buja LM, Sousa AL, Litovsky S, Lin J, Vaughn WK, Coutler S, Fernandes MR, Willerson JT. Comparison of intracoronary and transendocardial delivery of allogeneic mesenchymal cells in a canine model of acute myocardial infarction. J Mol Cell Cardiol 2008;44(3):486-495 [E-pub 2007 Oct 4].

  20. Jimenex-Quevedo P, Silva GV, Sanz-Ruiz R, Oliveira EM, Fernandes MR, Angeli F, Willerson JR, Dohmann HF, Perin EC. Diabetic and nondiabetic patients respond differently to transendocardial injection to bone marrow mononuclear cells: findings from prospective clinical trials in “no-option” patients. Rev Esp Cardiol 2008;61(6):635-639 [Spanish].

  21. Dohmann HF, Perin EC, Borojevic R, Silva SA, Souza AL, Silva GV, Assad JA, Rossi MI, Pascarelli BM, Assis IM, Dutra HS, Assad JA, Castello- Branco RV, Drummond C, Dohmann HJ, Willerson JT, Borojevic R. Transendocardial autologus bone marrow mononuclear cell injection in ischemic heart failure: postmortem anatomicopathologic and immunohistochemical findings. Circulation 2005;112(4):521-526.

  22. Dohmann HF, Perin EC, Borojevic R, Silva SA, Souza AL, Silva GV, Assad JA, Rossi MI, Mesquita CT, Dohmann HJ. Sustained improvement in symptoms and exercise capacity up to six months after autologous transendocardial transplantation of bone marrow mononuclear cells in patients with severe ischemic heart disease. Arq Bras Cardiol 2005;84(5):360-366.

  23. de Quadros AS, Sarmento-leite R, Gottschall CA, Silva GV, Perin EC. Hyperexpansion of coronary stents and clinical outcomes. Texas Heart Inst J. 2006;33(4):437-444.
  1. Perin, EC, Silva GV, Leite RS. Left ventricular electromechanical mapping as a diagnostic method. In: Myocardial Revascularization: Novel Percutaneous Approaches. George S Abela [Ed]. 2001: Wiley-Liss.

  2. Perin EC, Silva G. Stem cell therapy for cardiac diseases. In: Cardiovascular Medicine (3rd edition). Willerson JT, Cohn JN, Wellens HJJ, and Holmes DR [eds]. In press.

  3. Perin EC, Silva G. Stem cell therapy and cardiovascular disease. In: Cardiovascular Genetics and Genomics for the Cardiologist. Liew CC and Dzau V [eds]. 2007.

  4. Perin EC,  Silva GV. End-stage left ventricular failure: catheter-base stem cell therapy. In: Clinical Dilemmas in PCI. Lemos, Martinez, Ong, and Serruys, [eds]. In press.

  5. Perin EC, Silva GV, Willerson JT. Stem cell therapy in heart disease. In: Handbook of Vulnerable Plaque. 2007.

  6. Perin EC, Silva GV, Willerson JR. Stem cell therapy in ischemic heart disease. In: Treatment of Advanced Ischemic Heart Disease. Delgado R and Radovancevic B [eds]. In press.

  7. Silva GV, Perin EC. What are stem cells and what do they do? In: An Essential Guide to Cardiac Stem Cell Therapy. Perin EC, Silva GV, and Willerson JR [eds]. 2006: Abingdon: Informa UK Limited.

  8. Silva GV, Perin EC, Heinl-Green AC, Clague J, Alton EW. Stem cell delivery modalities. In: An essential guide to cardiac stem cell therapy. Perin E, Silva GV, Willerson JR [eds]. 2006:Abingdon: Informa UK Limited.

Books
  1. An essential guide to cardiac cell therapy. Perin EC, Silva GV, and Willerson JT [eds]. 2006: Informa.
  1. Perin EC, Silva GV, Fish RD, Vaughn WK, Leite RS. Noga: a window to the microvasculature? Immediate mechanical changes following PCI. Circulation 2000;3938;II:815.

  2. Leite RS, Silva GV, Vaughn W, Gottschall C, Perin EC. Predicting LV ejection fraction from electromechanical mapping: correlation with angiographic parameters. Am J Cardiol 2000;86:8A:108i.

  3. Perin EC, Silva GV, Leite RS. Rapid NOGA: a new mapping technique for navigation and accurate delivery of direct myocardial therapy. Am J Cardiol 2000;86:8A:108i.

  4. Perin EC, Howell M, Leite RS, Silva GV. Comparison between left ventricular electromechanical mapping and cardiac magnetic resonance imaging for detection of myocardial scar. Am J Cardiol 2000;86:8A:108i.

  5. Perin EC, Silva GV, Vaughn W, Fish RD, Leite RS. Left ventricular electromechanical mapping: a new perspective on immediate outcomes of coronary intervention. J Am Coll Cardiol 2001;37(2):Suppl A.

  6. Silva GV, Perin EC, Leite RS. New insights into the immediate changes in left ventricular voltage following PCI. J Am Coll Cardiol 2001;37(2):Suppl A.

  7. Perin EC, Howell M, Lambert B, Silva GV, Leite RS, Flamm S. Predicting hemodynamic data and presence of scar tissue from electromechanical mapping: correlation with cardiac magnetic resonance imaging. J Am Coll Cardiol 2001;37(2):Suppl A.

  8. Perin EC, Silva GV, Leite RS, Vaughn WK, Dohmann HF, Rocha RM Esporcatte R, Mesquita ET, Montera M, Gottschall CAM. Um novo metodo para a avaliacao da microcirculacao coronariana. [Oral presentation] Brazilian Cardiology Society Meeting, 2001.

  9. Dohmann HF, Perin EC, Carvalho LA, Mattos N, Leite RS, Silva GV, Montera M, Rocha RM, Ferreira FEG. Correlacao entre MEVE e SPECT na determinacao de dados volumetricos e funcionais do ventriculo esquerdo. [Oral presentation] Brazilian Cardiology Society Meeting, 2001.

  10. Sarmento-Leite R, Perin EC, Silva GV, Vaughn WK, Dohmann HF, Gonzalez C, Mattos N, Carvalho LA, Gottschall CAM. Uma nova technica para navegacao e revascularizacao miocardica direta do ventriculo esquerdo: mapas electromechanicos rapidos. Arq Bras Cardiol 2002;79(supp III):11.

  11. Perin EC, Dohmann HF, Silva GV, Sarmento-Leite RS, Mesquita CT, Moore W, Vaughn WK, Brizolara A, Mattos N, Dohmann HJ. Um novo metodo para deteccao de isquemia: mapeamento electromecanico de stress. Arq Bras Cardiol 2002;79(supp III):37.

  12. Sarmento-Leite RS, Perin EC, Silva GV, Brizolara A, Muthopillai R, Lampert B, Flamm S, Dohmann HF, Sousa A, Gottschall CAM. Mapeamento electromecanico do ventriculo esquerdo: uma comparacao com a ressonancia magnetica nuclear na deteccao de cicatriz miocardica e medida de parametros hemodinamicos. Arq Bras Cardiol 2002;79(supp III):61.

  13. Sarmento-Leite RS, Silva GV, Vaughn WK, Dohmann HF, Fonseca LM, Reis AG, Mesquita CT, Dohmann HJ, Gottschall CAM, Perin EC. Determinacao de miocardiopatia isquemica atraves de parametros electromecanicos. Arq Bras Cardiol 2002;79 supp III):63.

  14. Sarmento-Leite RS, Silva GV, Vaughn W, Dohmann HF, Gottschall CAM, Perin EC. Qual o significado de areas de baixa voltagem em mapas electromecanicos do ventriculo esquerdo. Arq Bras Cardiol 2002;79 (supp III):64.

  15. Sarmento-Leite RS, Silva GV, Vaughn WK, Dohmann HF, Mattos N, Carvalho LA, Gottschall CAM, Perin EC. Determinacao de parametros hemodinamicos e de motilidade ventricular segmentar: correlacao angiografica dos achados do mapeamento electromecanico do ventriculo esquerdo. Arq Bras Cardiol 2002;79 (supp III):88.

  16. Perin EC, Dohmann HF, Sarmento-Leite RS, Silva GV, Mesquita CT, Moore W, Carvalho LA, Feijo AL, Branco RC, Dohmann HJ. Otimizando a revascularizacao miocardica direta (RMD): uso do mapeamento electroemcanico de stress na deteccao de viabilidade miocardica. Arq Bras Cardiol 2002;79 (supp III):90.

  17. Perin EC, Dohmann HF, Borojevic R, Sousa AL, Dohmann HJ, Carvalho AC, Geng YJ, Silva GV, Rangel F, Silva SA, Esporcatte R, Willerson JT. Improvement in symptoms and exercise capacity at eight weeks in a controlled study of autologous bone marrow cell transplant in humans with severe ischemic heart failure. J Am Coll Cardiol 2003;823-1:44A.

  18. Dohmann HF, Perin EC, Sousa AL, Borojevic R, Carvalho AC, Rossi I, Silva SA, Esporcatte R, Silva GV, Dohmann HJ, Rangel F, Willerson JT. Safety of autologous bone marrow cell injection in humans with severe ischemic heart failure. J Am Coll Cardiol 2003;1176-176:67A.

  19. Perin EC, Dohmann HF, Borojevic R, Dohmann HJ, Carvalho AC, Geng YJ, Sousa AL, Silva GV, Rangel F, Silva SA, Rossi I, Esporcatte R, Willerson JT. Improvement in global and segmental left ventricular contractility following autologous bone marrow cell transplantation in humans with severe ischemic heart failure. J Am Coll Cardiol 2003;874-5:219A.

  20. Perin EC, Geng YJ, Sousa AL, Silva GV, Coulter S, Lin J, Ober J, Martin BJ, Willerson JT. Intramyocardial delivery of bone marrow-derived mesenchymal Stem Cells Improves Myocardial Contractility in a Chronic ischemic model. J Am Coll Cardiol 2003;1178-138:296A.

  21. Silva GV, Perin EC, Dohmann HF, Borojevic R, Silva SA, Sousa AL, Assad JA, Vaughn WK, Mesquita CT, Belem L, Carvalho AC, Dohmann HJ, Willerson JT. Improvement in MVO2 and reversible perfusion defects in candidates for heart transplant after transendocardial injection of autologous bone marrow derived mononuclear stem cells. Circulation 2003;108(17):IV-388.

  22. Perin EC, Dohmann HF, Borojevic R, Silva SA, Sousa AL, Silva GV, Mesquita CT, Belem L, Rangel RO, Assad JA, Carvalho AC, Rossi I, Dohmann HJ, Willerson JT. Improvement in exercise capacity and ischemia at six months following transendocardial injection of autologous bone marrow mononuclear cells for ischemic cardiomyopathy. Circulation 2003;108(17):IV-622.

  23. Assad JA, Silva GV, Perin EC, Dohmann HF, Silva SA, Sousa AL, Borojevic R, Vaughn WK, Dohmann HJ, Mesquita E. Are autologous bone marrow mononuclear stem cell injections a trigger for malignant ventricular arrhythmias? Circulation 2003;108(17):IV-688.

  24. Perin EC, Assad JA, Silva GV, Coulter S, Ober J, Lin J, Sousa AL, Litowski S, Geng Y, Martin BJ, Vaughn WK, Willerson JT. Comparison between intracoronary infusion and direct transendocardial injection of mesenchymal stem cells in a dog acute ischemia model. J Am Coll Cardiol 2004;43(5A):1100-56:63A.

  25. Perin EC, Dohmann HF, Borejevic R, Assad JA, Silva GV, Silva SA, Sousa AL, Vaughn WK, Rossi I, Carvalho AC, Geng YJ, Dohmann HJ, Willerson JT. Transendocardial injection of autologous bone marrow mononuclear cells may enhance myocardial viability around cell injection site. J Am Coll Cardiol 2004;43(5A):814-1:186A.

  26. Perin EC, Dohmann HF, Borejevic R, Silva SA, Sousa AL, Silva GV, Assad JA, Belem L, Carvalho AC, Esporcatte R, Vaughn WK, Dohmann HJ, Willerson JT. Time course of improvement following stem cell injections in humans with heart failure. J Am Coll Cardiol 2004;43(5A):814-2:187A.

  27. Fernandes MR, Silva GV, Oliveira Edie M, Sanz RR, Jimenez-Quevedo P, Angeli FS, Zheng Y, Baimbridge FA, Canales J, Cardoso CO, Silviu I, Willerson JT, Perin EC. Assessment of efficacy with allogenic mesenchymal precursor cells: a targeted translational model of acute MI. 56th Annual Scientific Session.

  28. Fernandes MR, Silva GV, Oliveira EM, Sanz RS, Jimenez-Quevedo P, Angeli FS, Zheng Y, Baimbridge FA, Canales J, Cardoso CO, Itescu S, Willerson JT, Perin EC. Assessment of efficacy with allogenic mesenchymal precursor cells: a targeted translational model of acute MI. American College of Cardiology, 2007.

  29. Perin EC, Silva GV, Munger R, Pandey A, Sehra R, Talcott M, Bichard C, Creed J, Wong J, Oliveira EM, Zheng Y, Canales J, Angeli FS, Cardoso CO, Fernandes MR, Willerson JT. First experience with remote LV mapping and injection utilizing a novel integrated NOGA XP/Stereotaxis platform. ACC, 2007.

  30. Quevedo-Jimenez P, Silva GV, Ruiz RS, Angeli FS, Oliveira EM, Fernandes MR, Baimbridge FA, Smith D, Westbrook L, Dohmann HF, Cardoso CO, Zheng Y, Canales J, Willerson JT, Perin EC. Lack of clinical response in diabetic patients after transendocardial injection of bone marrow mononuclear cells. ACC, 2007.

  31. Fernandes MR, Silva GV, Oliveira E, Angeli F, Sanz R, Jimenez-Quevedo P, Assad JA, Branco R, Lopez J, Clubb F, Vaughn W, Patel DD, Baimbridge F, Perin EC. Drug eluting stents and delayed arterial healing: paclitazel eluting stents are associated with increased arterial wall inflammatory changes when compared to sirolimus eluting stents in a porcine restenosis model. AHA, 2006.

  32. Silva GV, Fernandes MR, Assad JA, Oliveira E, Branco R, Lopez J, Angeli F, Jimenez-Quevedo P, Sanz R, Vaughn W, Patel D, Baimbridge F, Cardoso CO, Zheng Y, Falotico R, Willerson JT, Perin EC. Drug eluting stents and delayed arterial healing: sirolimus eluting stents are associated with impaired endothelial maturation and increased fibrin deposition in a porcine restenosis model. Cardiovascular Research Foundation 2006/TCT 2006.